Unique sodium-caged structure of a potent endothelin-1 inhibitor: crystal structure of BQ123 sodium salt, cyclo(-D-Trp-D-Asp−-Pro-D-Val-Leu-)·Na+

Mitsunobu Doi; Toshimasa Ishida; Yoshio Katsuya; Yoshihiro Mezaki; Masahiro Sasaki; Akira Terashima; Taizo Taniguchi; Hiroshi Hasegawa; Masaaki Shiono

doi:10.1039/A909413J

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Unique sodium-caged structure of a potent endothelin-1 inhibitor: crystal structure of BQ123 sodium salt, cyclo(-d-Trp-d-Asp⁻-Pro-d-Val-Leu-)·Na⁺

Mitsunobu Doi,*^a Toshimasa Ishida,^a Yoshio Katsuya,^b Yoshihiro Mezaki,^b Masahiro Sasaki,^c Akira Terashima,^c Taizo Taniguchi,^c Hiroshi Hasegawa^c and Masaaki Shiono^d

Author affiliations

* Corresponding authors

^a Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, Japan.
E-mail: doit@oysun01.oups.ac.jp

^b Hyogo Prefectural Institute of Industrial Research, 3-1-12 Yukihira-cho, Suma, Kobe, Japan

^c Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji, Japan

^d Kyushu University, Hakozaki, Higashi-ku, Fukuoka-shi, Japan

Abstract

The crystal structure of cyclo(D-Trp-D-Asp⁻-Pro-D-Val-Leu-)·Na⁺, a potent endothelin-1 antagonist, showed four conformational isomers and two Na⁺-caged structures in pairs.

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Supplementary files

Crystal data TXT (74K)

Article information

DOI: https://doi.org/10.1039/A909413J
Article type: Communication
Submitted: 28 Nov 1999
Accepted: 20 Mar 2000
First published: 17 Apr 2000

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Chem. Commun., 2000, 743-744

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Unique sodium-caged structure of a potent endothelin-1 inhibitor: crystal structure of BQ123 sodium salt, cyclo(-D-Trp-D-Asp⁻-Pro-D-Val-Leu-)·Na⁺

M. Doi, T. Ishida, Y. Katsuya, Y. Mezaki, M. Sasaki, A. Terashima, T. Taniguchi, H. Hasegawa and M. Shiono, Chem. Commun., 2000, 743 DOI: 10.1039/A909413J

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Chemical Communications