The first totally synthetic base-modified analogues of the natural product and potent D-myo-inositol 1,4,5-trisphosphate receptor agonist adenophostin A were efficiently synthesised from D-xylose and D-glucose using methodology employing base and surrogate base addition to a common disaccharide intermediate.
Convergent synthesis of adenophostin A analogues via a base replacement strategy
R. D. Marwood, S. Shuto, D. J. Jenkins and B. V. L. Potter, Chem. Commun., 2000, 219 DOI: 10.1039/A909347H
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