Radical cyclization of O-trityl oximino esters: a ring closure that preserves the oxime function
Abstract
O-Trityl oximino esters 1 undergo stannane-induced radical cyclization to regenerate an oxime function, affording oximino lactones 4; these can be converted into enamides (e.g. 11b), and such a transformation was used to make the natural product 14c.