Multi-functionalization of oligodeoxynucleotide: a facile post-synthetic modification technique for the preparation of oligodeoxynucleotides with two different functional molecules

Abstract

Treatment of the support-bound novel multi-functionalizable oligodeoxyribonucleotides bearing both 5-cyanomethoxycarbonylmethyl- and 5-methoxycarbonylmethyl-uridine with tyramine followed by tris(2-aminoethyl)amine facilitated multi-functionalization of oligodeoxyribonucleotides having different amine molecules.