Adsorptive stripping voltammetric determination of ketoconazole in pharmaceutical preparations and urine using carbon paste electrodes

Abstract

The oxidation of ketoconazole on a bare carbon paste electrode was studied voltammetrically. The results indicated that the process is irreversible and controlled by an adsorption–extraction process which allows the accumulation of the drug at the electrode surface. After the optimization of solution pH, accumulation variables and instrumental parameters, sensitive differential pulse and linear sweep voltammetric peaks were obtained whose peak currents were linearly proportional to the ketoconazole concentration over the ranges 2.4 × 10⁻⁸–4.8 × 10⁻⁷ and 9.1 × 10⁻⁷–1.0 × 10⁻⁵ M, respectively. Based on these findings, a simple procedure was developed for the determination of ketoconazole in human urine and formulations.