Issue 10, 1999

Contribution of microwaves in organic synthesis: statement of a methodology for the microwave-induced preparation of benzofuran-2(3H )-one and its comparison with classical heating

Abstract

The intramolecular cyclisation of 2-hydroxyphenylacetic acid 1 into coumaran-2-one 2 was studied under both microwave irradiation and classical heating for comparison purposes. The use of a monomode oven allowed an accurate consideration of the temperature distribution in the microwave reaction vessel, which revealed a very strong and unexpected thermal heterogeneity. The reaction was facilitated by the presence of a trace of toluene-p-sulfonic acid, the catalytic role of which is demonstrated.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1999, 2111-2115

Contribution of microwaves in organic synthesis: statement of a methodology for the microwave-induced preparation of benzofuran-2(3H )-one and its comparison with classical heating

P. Goncalo, C. Roussel, J. Marie Mélot and J. Vébrel, J. Chem. Soc., Perkin Trans. 2, 1999, 2111 DOI: 10.1039/A904159A

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