Transition structures of intramolecular ene reactions in the presence of activating substituents: a theoretical study

Abstract

Transition states of intramolecular ene reactions in the presence of an activating substituent were studied by an AM1 approximation to calculate the proportion of various diastereomeric products. The predicted diastereoselectivity for the formation of a five membered ring containing chiral and/or achiral centres was found to be in good agreement with the reported experimental observations.