Conformational equilibria in amino steroids derived from fusidic acid
Abstract
The conformation of ring A of the 3α-hydroxy-2β-piperidino steroid 9, derived from fusidic acid, has been investigated by 1H NMR and is determined by the polarity of the medium: it is primarily in a twist-boat conformation in a non-polar solvent and a chair conformation in a polar solvent.