Issue 24, 1999

High yielding synthesis of dehydroamino acid and dehydropeptide derivatives

Abstract

By using a 4-dimethylaminopyridine (DMAP) catalysed reaction of β-hydroxyamino acid derivatives with tert- butyl pyrocarbonate [(Boc)2O], dehydroamino acid derivatives are obtained in high yields. The same methodology applied to dipeptides with a β-hydroxyamino acid residue gives the corresponding dipeptides with a dehydroamino acid residue.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1999, 3697-3703

High yielding synthesis of dehydroamino acid and dehydropeptide derivatives

P. M. T. Ferreira, H. L. S. Maia, L. S. Monteiro and J. Sacramento, J. Chem. Soc., Perkin Trans. 1, 1999, 3697 DOI: 10.1039/A904730A

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