SCHEDULED MAINTENANCE
A prostaglandin-F1α methyl ester derivative (12) possessing three different protecting groups on the hydroxy units was prepared so as to allow selective removal of the group attached to the 11-OH group. Compound (12) was converted into prostaglandin-J1 methyl ester (16) in two steps (77% overall yield). Prostaglandin-J1 methyl ester showed potent activity against Sendai virus.
S. M. Roberts, M. Gabriella Santoro and T. Guyot, J. Chem. Soc., Perkin Trans. 1, 1999, 2437 DOI: 10.1039/A903813B
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