Potentially carcinogenic cyclopenta[a]phenanthrenes. Part 13. Synthesis of the 11-trifluoro, 11-cyano, and 11-amino analogues of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one
Abstract
The preparation of 11,12,13,14,16,17-hexahydro-15H-cyclopenta[a]phenanthren-11,17-dione has been optimised, and the derived 17,17-ethylene diketal has been employed in the synthesis of the bay-region 11-trifluoromethyl-, 11-cyano-, and 11-amino-15,16-dihydrocyclopenta[a]phenanthren-17-ones.