Issue 20, 1999

Potentially carcinogenic cyclopenta[a]phenanthrenes. Part 13. Synthesis of the 11-trifluoro, 11-cyano, and 11-amino analogues of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one

Abstract

The preparation of 11,12,13,14,16,17-hexahydro-15H-cyclopenta[a]phenanthren-11,17-dione has been optimised, and the derived 17,17-ethylene diketal has been employed in the synthesis of the bay-region 11-trifluoromethyl-, 11-cyano-, and 11-amino-15,16-dihydrocyclopenta[a]phenanthren-17-ones.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1999, 3019-3022

Potentially carcinogenic cyclopenta[a]phenanthrenes. Part 13. Synthesis of the 11-trifluoro, 11-cyano, and 11-amino analogues of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one

M. M. Coombs, J. Chem. Soc., Perkin Trans. 1, 1999, 3019 DOI: 10.1039/A902329A

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