Highly stereoselective metal-catalyzed epoxidation of hydroxy vinyl sulfones1
Abstract
Acyclic α-hydroxyalkyl α,β-unsaturated sulfoxides undergo oxidation at sulfur followed by a highly regio- and stereoselective epoxidation at the electron deficient alkene by treatment with ButOOH–VO(acac)2; this methodology allows for an expedient entry into unusual carbohydrate fragments.