Issue 9, 1999

Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

Abstract

Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 µM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl m-methylhydroquinone occurring in a higher terrestrial plant.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1999, 1147-1150

Chrysochlamic acid, a new diterpenoid-substituted quinol from Chrysochlamys ulei that inhibits DNA polymerase β

J. Deng, D. Sun, S. R. Starck, S. M. Hecht, R. L. Cerny and J. R. Engen, J. Chem. Soc., Perkin Trans. 1, 1999, 1147 DOI: 10.1039/A901123D

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