Issue 9, 1999

Convenient synthesis of C-aza-2,3-dideoxynucleosides

Abstract

1-Aryl-1,2,3,4-tetradeoxy-1,4-imino-D-pentitols 5 and 9f are easily synthesized from N-Boc-L-pyroglutamate 1 via a successive procedure involving regioselective ring-opening, recyclization with dehydration, stereoselective reduction, and reduction of the ester group. Their structures are determined mainly by X-ray crystallography and NMR measurements. Their bioassay is also described.

Supplementary files

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1999, 1193-1200

Convenient synthesis of C-aza-2,3-dideoxynucleosides

A. Momotake, H. Togo and M. Yokoyama, J. Chem. Soc., Perkin Trans. 1, 1999, 1193 DOI: 10.1039/A900689C

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