Issue 6, 1999

Sequential radical cyclization of β-functionalized allyl bromomethyldimethylsilyl ethers. Application to the regio- and stereo-specific synthesis of an isoprostanoid precursor

Abstract

The behaviour of allyl bromomethyldimethylsilyl ethers β-substituted by various radical trapping functions (aldehyde, nitrile or acetylenic) is studied in tandem radical cyclizations. Only homopropargylic ethers (but-3-ynylic ethers) lead to the formation of cyclic compounds via a 5-exo-trig, 5-exo-dig or 5-exo-trig, 6-endo-dig mode. The influence of the TMS group located on the acetylenic moiety is shown to be determinant for the regio- and stereo-specific C5 ring closure (5-exo-dig mode).

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1999, 697-704

Sequential radical cyclization of β-functionalized allyl bromomethyldimethylsilyl ethers. Application to the regio- and stereo-specific synthesis of an isoprostanoid precursor

F. Belval, A. Fruchier, C. Chavis, J. Montero and M. Lucas, J. Chem. Soc., Perkin Trans. 1, 1999, 697 DOI: 10.1039/A809281H

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