Asymmetric synthesis of (2R,3S)-2,3-epoxyamides via camphor-derived sulfonium ylides
Abstract
Enantiomerically enriched trans-2,3-epoxyamides 3 were prepared by the reaction of aldehydes 2 with camphor-derived chiral sulfonium ylide 1 in good yields and moderate to good ee values. The absolute configuration of the reaction product is also determined by chemical transformations.