First syntheses of the pyrroloketopiperazine marine natural products (±)-longamide, (±)-longamide B, (±)-longamide B methyl ester and (±)-hanishin
Abstract
The marine natural products (±)-longamide (1), (±)-longamide B methyl ester (2), (±)-longamide B (3) and (±)-hanishin (4), each of which embodies a pyrroloketopiperazine core, have been synthesised in a concise fashion from pyrrole.