Issue 6, 1999

Cyclic (4S)-chloromethyl sulfite and sulfate derivatives of (S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin

Abstract

The interaction of (S)-glycidol with SOCl2 or SO2Cl2 in stoichiometric amounts leads to the formation of cyclic (4S)-chloromethyl sulfite or sulfate derivatives with the same enantiomeric purity; based on this reaction, a new procedure for the synthesis of (S)-propranolol was developed.

Article information

Article type
Paper

Mendeleev Commun., 1999,9, 236-238

Cyclic (4S)-chloromethyl sulfite and sulfate derivatives of (S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin

A. A. Bredikhin, S. N. Lazarev, A. V. Pashagin and Z. A. Bredikhina, Mendeleev Commun., 1999, 9, 236 DOI: 10.1070/MC1999v009n06ABEH001190

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