Diastereoselective Synthesis of N-Protected β-Amino-α-hydroxyacids (Norstatines) from Urethane N-Carboxyanhydrides (UNCAs)
Abstract
β-Amino-α-hydroxyacids (norstatines) are prepared from urethane N-protected carboxyanhydrides (UNCAs); the key step is the diastereoselective reduction of a keto-acetylenic compound, which lead is, with syn diastereoselectivity, to the corresponding propargylic alcohol.