Tin-mediated Organic Reactions: a Practical Method for the Synthesis of β-Hydroxynitriles and β-Hydroxyketones
Abstract
In the presence of chlorotrimethylsilane, the tin mediated addition of bromoacetonitrile or α-bromacetophenone to aldehydes in THF gives β-hydroxynitriles or β-hydroxyketones in moderate to good yields.