A Key Intermediate towards Oxylipins. A Formal Synthesis of (12S)-HETE and (12S)-LTB4
Abstract
A key intermediate in the synthesis of various oxylipins, the optically active (3S,5Z)-3-methoxymethoxyundec-5-en-1-yne, has been obtained in 11 steps starting from propane-1,3-diol, with an overall yield of 14%.