Clay-catalyzed Conversion of 2,2-Disubstituted Malononitriles to 2-Oxazolines: Towards Unnatural Amino Acids
Abstract
Acidic clay catalyzed reaction of malononitrile derivatives with an excess of 1,2-aminoalcohol furnishes mono-oxazolines selectively; a simple strategy to prepare 2,2-dialkyl-3-aminopropionic acid derivatives is presented.