Issue 2, 1999

Synthesis and Reactivity of 3-Alkylthio-5-cyanomethyl-4-phenyl-1,2,4-triazoles

Abstract

Phenyl isothiocyanate reacts with 2-cyanoacetohydrazide (1) to yield the corresponding 1-cyanoacetyl-4-phenyl-thiosemicarbazide (3), via acid hydrolysis of the intermediate 2 whereas cyclization of 3 gave the 1,2,4-triazoles 4, 1,3,4-thiadiazoles 7 and 1,3,4-thiadiazine-5-ones 9; compound 4a was reacted with phenyl isothiocyanate, dicyandiamide, sulfanylacetic acid and benzaldehyde to afford 11, 13, 14 and 15, respectively.

Article information

Article type
Paper

J. Chem. Res. (S), 1999, 76-77

Synthesis and Reactivity of 3-Alkylthio-5-cyanomethyl-4-phenyl-1,2,4-triazoles

R. A. Mekheimer and R. M. Shaker, J. Chem. Res. (S), 1999, 76 DOI: 10.1039/A806842I

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