Synthesis of platinum(II) complexes of thymidine and 1-methylthymine (1-MeThy); crystal structure of cis-[PtCl(1-MeThy)(PPh3)2]

Abstract

The reaction of 3′,5′-di-O-acetylthymidine with [Pt(PPh₃)₄] and KCl yielded a platinum(II) complex where the platinum is co-ordinated to the nucleobase through the N3 atom. In a similar reaction 1-methylthymine (1-MeThy) furnished the complex cis-[PtCl(1-MeThy)(PPh₃)₂], whose structure was determined by spectroscopic data and single crystal X-ray diffraction. When 1-MeThy was treated with [Pt(PPh₃)₄] in the absence of chloride ions the complex trans-[Pt(OH)(1-MeThy)(PPh₃)₂] was obtained.