Issue 23, 1999

General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis

Abstract

The hydrolysis of the four-membered ring sulfonamide N-benzyl β-sultam is catalysed by carboxylic acids, which is attributed to specific acid–nucleophilic catalysis with the intermediate formation of a mixed anhydride which can be trapped with aniline.

Article information

Article type
Paper

Chem. Commun., 1999, 2401-2402

General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis

N. J. Baxter, A. P. Laws, L. J. H. Rigoreau and M. I. Page, Chem. Commun., 1999, 2401 DOI: 10.1039/A907501A

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