Novel concise synthesis of 2-substituted 3,4-dihydro-2H-1,4-benzoxazines by ring opening of glycidols under solid-liquid phase transfer catalysis conditions†

Abstract

The ring opening of glycidols with N-(2-fluorophenyl)toluene-p-sulfonamide under SL-PTC conditions, followed by ring closure with Bu^tOK, provides a novel high yielding synthesis of 2-substituted 3,4-dihydro-2H-1,4-benzoxazines.