Opposite influence of calf thymus DNA on the rate of substitution of ethylenediamine, by thiourea, in the complex cations [Pd(bpy)(en)]2+ and [Pd(bromazepam)(en)]2+ (bromazepam = 7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one)

Abstract

Calf thymus DNA inhibits the substitution of ethylenediamine, by thiourea, in [Pd(bpy)(en)]²⁺ and catalyses the same reaction in [Pd(bromazepam)(en)]²⁺ (bromazepam = 7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one); this kinetic effect can be related to the different binding modes of the two complexes to the biopolymer.