Issue 17, 1999

A novel approach to site-specifically platinated oligonucleotides applying combinations of nucleobase protecting groups

Abstract

Platination of a properly protected oligonucleotide followed by deprotection represents a new method for the synthesis of site-specific platinum-modified nucleic acids; N7 platination of 2′-deoxyguanosine can be circumvented by introducing a bulky protective group at the O6 position.

Article information

Article type
Paper

Chem. Commun., 1999, 1693-1694

A novel approach to site-specifically platinated oligonucleotides applying combinations of nucleobase protecting groups

R. J. Heetebrij, R. A. Tromp, G. A. van der Marel, J. H. van Boom and J. Reedijk, Chem. Commun., 1999, 1693 DOI: 10.1039/A904365I

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