Heterobifunctional glycopeptide 1 composed of Neu5Acα-(2→3)Galβ(1→4)[Fucα(1→3)]GlcNAc (sialyl Lewisx) and Lys-Gly-Arg-Gly-Asp-Ser (KGRGDS) having specific activity to bind concurrently with two different types of cell adhesive molecules such as selectins and integrins was synthesised on the basis of a combined chemical and enzymatic strategy.
S. Nishimura, M. Matsuda, H. Kitamura and T. Nishimura, Chem. Commun., 1999, 1435 DOI: 10.1039/A904362D
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