Biosynthesis of XR587 (streptopyrrole) in Streptomyces rimosus involves a novel carbon-to-nitrogen rearrangement of a proline-derived unit
Abstract
Results from incorporation studies with 13C-labelled acetate, propionate and proline establish a polyketide origin for the pyrrole-containing streptomycete metabolite, XR587, and are in accord with the formation of an amide bond via an unprecedented rearrangement of a proline-derived starter unit.