Exploring a chemical encoding strategy for combinatorial synthesis using Friedel–Crafts alkylation
Abstract
The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel–Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b–i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.