Catalytic enantioselective addition of enol silanes to ketomalonate mediated by C2-symmetric bisoxazoline Lewis acid complexes

Abstract

A catalytic enantioselective addition reaction of silyl enol ethers to ketomalonate in the presence of C₂-symmetric copper(II) bisoxazolines as catalysts is presented; the reaction has been studied for different ligands and substrates under various reaction conditions and proceeds in good yield and with ee’s >90% and a procedure for the preparation of an optically active hydroxy acid is shown.