Issue 12, 1999

Novel reagents for targeted cleavage of RNA sequences: towards a new family of inorganic pharmaceuticals

Abstract

Copper kanamycin degrades cognate RNA targets at concentrations as low as picomolar levels at physiological pH and temperature, but shows no chemistry with random RNA or DNA molecules, thereby demonstrating potential for development as a novel antiviral agent.

Article information

Article type
Paper

Chem. Commun., 1999, 1147-1148

Novel reagents for targeted cleavage of RNA sequences: towards a new family of inorganic pharmaceuticals

A. Sreedhara, A. Patwardhan and J. A. Cowan, Chem. Commun., 1999, 1147 DOI: 10.1039/A901140D

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