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Issue 8, 1999
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Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by isopentenyl diphosphate:dimethylallyl diphosphate isomerase

Abstract

The interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) catalyzed by E. coli and S. pombe IPP isomerase proceeds with removal of the pro-R proton at C2 of IPP and addition of a water-derived proton to the re face of the C2–C3 double bond in DMAPP; this is the same stereochemistry observed for S. cerevisiae and rat liver enzymes.

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Article information


Chem. Commun., 1999, 717-718
Article type
Paper

Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by isopentenyl diphosphate:dimethylallyl diphosphate isomerase

A. E. Leyes, J. A. Baker, F. M. Hahn and C. Dale Poulter, Chem. Commun., 1999, 717
DOI: 10.1039/A900621D

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