A practical approach to galactose–PEG–distearoylphosphatidic acid (DSPA) retaining full lectin binding, involves glycosylation of monobenzyl ether–PEG, suitable protection of the sugar hydroxy groups, debenzylation, followed by enzymatic transphosphatidylation with phosphatidylcholine and final deprotection.
S. Zalipsky, N. Mullah, A. Dibble and T. Flaherty, Chem. Commun., 1999, 653 DOI: 10.1039/A900355J
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