Two nonproteinogenic amino acids 5 and 6 have been efficiently prepared using an SH2′ allylstannane coupling reaction and a Wittig reaction, respectively, to effect the key steps; kinetic studies show these compounds to be reversible inhibitors of DAP dehydrogenase with Ki values of 5.3 (competitive) and 44 µM (noncompetitive), respectively.
A. Sutherland, J. F. Caplan and J. C. Vederas, Chem. Commun., 1999, 555 DOI: 10.1039/A900297I
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