Gas chromatographic determination of some alkoxysilanes for use in occupational exposure assessment

Abstract

The manufacture and application of organosilicon compounds, especially silanes, have increased dramatically during recent decades. This has led to an increase in the number of exposed workers in different areas of industry. Therefore, there is an urgent need for an analytical method which can assess exposure to these compounds. A capillary column gas chromatographic (GC) method was developed for detecting 3-methacryloxypropyltrimethoxysilane, 3-glycidoxypropyltrimethoxysilane and 3-aminopropyltriethoxysilane. The silanes diluted in heptane were analysed by GC using flame ionisation detection. Gas chromatography–mass spectrometry was used to confirm the identity of the GC peaks. The analytical range of the method varied from 1 or 5 µg ml^–1 to 500 µg ml^–1 depending on the silane being studied. The detection limits were 1 µg ml ^–1 for 3-methacryloxypropyltrimethoxysilane and 3-glycidoxypropyltrimethoxysilane and 5 µg ml^–1 for 3-aminopropyltriethoxysilane. The mean recovery of silanes tested with patch samples was >95% for all of the silanes. The repeatability of the patch sample method for silanes varied from 6.5 to 10.1%. This new GC method allows the simultaneous determination of three organosilicon compounds for occupational exposure assessment.