Issue 3, 1998

Double-helical nucleic acids with cross-linked strands: synthesis and applications in molecular biology

Abstract

Data on the methods employed for cross-linking of DNA strands and for the synthesis of oligonucleotide duplexes with cross-links between strands are summarised. Existing methods are systematised; their advantages and drawbacks are discussed. The examples of applications of DNA duplexes with covalently cross-linked chains for the study of protein–nucleic acid recognition and mechanisms of action of nucleic acid-binding proteins for gaining information about the spatial structure of nucleic acids, and for the solution of other problems of molecular biology are given. The bibliography includes 131 references.

Article information

Article type
Paper

Russ. Chem. Rev., 1998,67, 245-262

Double-helical nucleic acids with cross-linked strands: synthesis and applications in molecular biology

S. I. Antsypovich and T. S. Oretskaya, Russ. Chem. Rev., 1998, 67, 245 DOI: 10.1070/RC1998v067n03ABEH000345

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