Issue 1, 1998

Biosynthesis of amphotericin B

Abstract

The high level incorporation of isotopically labelled sodium acetate and sodium propionate into amphotericin B is reported. Double quantum filtered heteronuclear single quantum coherence NMR (DQF-HSQC) is employed to demonstrate coupling between labelled carbons on intact acetate units after biosynthesis. Electrospray mass spectroscopy demonstrates the high level incorporation of label is present in only half the molecules, the other half remaining unlabelled.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1998, 83-88

Biosynthesis of amphotericin B

C. M. McNamara, S. Box, J. M. Crawforth, B. S. Hickman, T. J. Norwood and B. J. Rawlings, J. Chem. Soc., Perkin Trans. 1, 1998, 83 DOI: 10.1039/A704545J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements