Assembly of dendritic glycoclusters from monomeric mannose building blocks
Abstract
Mannoside-based dendrimers were prepared by tetrafold glycosidation of selenium-donors with branched alcohol scaffolds. A trisaccharide-based glycocluster could be assembled in one reaction vessel based on reactivity tuning of glycosyl fluorides, orthogonal coupling to a glycosyl selenide and subsequent capture onto the dendritic scaffold.