The synthesis of a series of N-(protected)aminophthalimides and the removal of their phthaloyl group leading to N-(protected) or N,N-bis(protected)hydrazines is described. As illustrated by the synthesis of monolabelled isoniazid 3b*, this strategy can be utilized for the preparation of monolabelled substituted hydrazines.
N. Brosse, M. Pinto and B. Jamart-Grégoire, J. Chem. Soc., Perkin Trans. 1, 1998, 3685 DOI: 10.1039/A807230B
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