Synthesis of the A/E/F sections of conaconitine, napelline and related diterpenoid alkaloids of the aconitine group
Abstract
The tricyclic amines (±)-2; R = H and R = Me with five stereogenic centres, representing the A/E/F ring system of the title alkaloids, have been synthesised from penta-1,4-dien-3-ol in eight (overall yield 20%) and nine steps (overall yield 16%) respectively.