Diastereoselective synthesis of (–)-N-acetylneuraminic acid (Neu5Ac) from a non-carbohydrate source
Abstract
cis-1,2-Dihydrocatechol 2, a product of microbial oxidation of chlorobenzene, has been converted into a protected form, 17, of (–)-Neu5Ac (1) via a fifteen step reaction sequence.