Parasite glycoconjugates. Part 8.1 Chemical synthesis of a heptaglycosyl triphosphate fragment of Leishmania mexicana lipo- and proteo-phosphoglycan and of a phosphorylated trisaccharide fragment of Leishmania donovani surface lipophosphoglycan

Abstract

The phosphorylated branched heptasaccharide β-D-Galp-(1→4)-α-D-Manp-(1-PO₃H-6)-[β-D-Glcp-(1→3)]-β-D-Galp-(1→4)-α-D-Manp-(1-PO₃H-6)-β-D-Galp-(1→4)-α-D-Manp-1-PO₃H-O[CH₂]₈CHCH₂, which is a fragment of the phosphoglycan portion of Leishmania mexicana lipophosphoglycan and proteophosphoglycan, has been synthesized using the thioglycoside and Helferich methods for the glycosylations and the glycosyl hydrogenphosphonate method for the successive introduction of the disaccharide phosphate and trisaccharide phosphate blocks.