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Issue 14, 1998
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Artemisinin mediated alteration of haemin to a δ-meso oxidation product: relevance to mechanism of action

Abstract

Antimalarial drug artemisinin and haemin react in vitro, to give a δ-meso hydroxy porphyrin isolated as a stable dimethyl esterified zinc complex and characterised as (20-hydroxyprotoporphyrinato dimethyl ester)zinc(II) by NOESY, visible absorption and ESI-MS; the structure sheds light on the mechanism of action of endoperoxide antimalarials.

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Article type: Paper
DOI: 10.1039/A802423E
J. Chem. Soc., Perkin Trans. 1, 1998, 2163-2166

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    Artemisinin mediated alteration of haemin to a δ-meso oxidation product: relevance to mechanism of action

    S. Bharel, R. A. Vishwakarma and S. K. Jain, J. Chem. Soc., Perkin Trans. 1, 1998, 2163
    DOI: 10.1039/A802423E

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