SCHEDULED MAINTENANCE
Antimalarial drug artemisinin and haemin react in vitro, to give a δ-meso hydroxy porphyrin isolated as a stable dimethyl esterified zinc complex and characterised as (20-hydroxyprotoporphyrinato dimethyl ester)zinc(II) by NOESY, visible absorption and ESI-MS; the structure sheds light on the mechanism of action of endoperoxide antimalarials.
S. Bharel, R. A. Vishwakarma and S. K. Jain, J. Chem. Soc., Perkin Trans. 1, 1998, 2163 DOI: 10.1039/A802423E
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