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Issue 14, 1998
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Synthesis and properties of C-aza-2-deoxy-L-lyxonucleosides

Abstract

C-Aza-2-deoxy-L-lyxonucleosides’ in which a sugar ring oxygen is replaced with a nitrogen atom are synthesized from 2-deoxy-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-D-erythro-pentofuranose via a sequential procedure of the addition of lithium salts of aromatic heterocycles, Swern oxidation and reductive aminocyclization. Their structures are determined mainly by X-ray crystallography and NMR measurements. Their bioassay is also described.

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Article information


J. Chem. Soc., Perkin Trans. 1, 1998, 2185-2192
Article type
Paper

Synthesis and properties of C-aza-2-deoxy-L-lyxonucleosides

M. Yokoyama, T. Ikeue, Y. Ochiai, A. Momotake, K. Yamaguchi and H. Togo, J. Chem. Soc., Perkin Trans. 1, 1998, 2185
DOI: 10.1039/A802247J

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