Issue 11, 1998

Synthesis of myo-inositol 4,6-cyclic,1,5-trisphosphate, a conformationally restricted analogue of myo-inositol 1,4,5-trisphosphate

Abstract

myo-Inositol 4,6-cyclic,1,5-trisphosphate 2 has been prepared starting from myo-inositol. The suitably protected intermediates, obtained by judicious selective protections and deprotections, have been phosphorylated. Final one-pot deprotection gives the expected, conformationally restricted, analogue of myo-inositol 1,4,5-trisphosphate. The physico-chemical behaviour of this derivative could explain its biological inactivity.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1998, 1859-1864

Synthesis of myo-inositol 4,6-cyclic,1,5-trisphosphate, a conformationally restricted analogue of myo-inositol 1,4,5-trisphosphate

S. Ballereau, S. N. Poirier, G. Guillemette, B. Spiess and G. Schlewer, J. Chem. Soc., Perkin Trans. 1, 1998, 1859 DOI: 10.1039/A800311D

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