Issue 8, 1998

A new route to ene carbamates, precursors to benzoindolizinones through sequential asymmetric hydrogenation and cyclization

Abstract

New pyrrolidine-based ene carbamates have been efficiently synthesized and the first example of asymmetric hydrogenation of this kind of substrate is reported, leading to the preparation of 2-arylmethylpyrrolidine precursors to benzoindolizinones in high yields and enantioselectivities up to 57%.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1998, 1403-1408

A new route to ene carbamates, precursors to benzoindolizinones through sequential asymmetric hydrogenation and cyclization

A. Couture, E. Deniau, S. Lebrun, P. Grandclaudon and J. Carpentier, J. Chem. Soc., Perkin Trans. 1, 1998, 1403 DOI: 10.1039/A709053F

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