Asymmetric synthesis of (2R,4R,5S)-tetrahydropseudodistomin and stereoisomers by cycloaddition of nitrone to vinylglycinol1
Abstract
Cycloaddition of the nitrone, derived from tetradecanal, to vinylglycinol provides an asymmetric synthesis of both (2R,4R,5S)-tetrahydropseudodistomin and all the stereoisomers of the racemic tetrahydropseudodistomins.