A novel calix[6]arene-based mononuclear copper(I) complex that exhibits chirality at low temperature

Abstract

A calix[6]arene functionalized in alternate positions at the lower rim with three picolyl groups acts as a biomimetic N3 ligand with cuprous ion. The stable C₃ symmetrical complex derived from CuCl exists as a pair of helical enantiomers. A low temperature ¹H NMR study revealed that the chirality is transmitted to the calixarene skeleton, thereby providing a chiral cavity around the apical binding site of the metal center.